Repeated USMLE Questions Step 1 Review-159- Pharmacology

Q- A patient taking allopurinol for gout should be closely monitored for which serious adverse effect? A- Aplastic anemia B- Hepatotoxicity C- Severe hypersensitivity reaction D- Thrombocytopenia   Q- A patient with asthma is prescribed propranolol and develops worsening shortness of breath. What explains this effect? A- Alpha-1 receptor blockade B- Beta-1 receptor stimulation C- … Read more

Repeated USMLE Questions Step 1 Review-158- Pathology

Q- A 59-year-old man presents with progressive dysphagia. Endoscopy reveals an ulcerated mass in the distal esophagus. Biopsy shows malignant gland-forming cells. Which risk factor is most strongly associated with this condition? A- Alcohol consumption B- Chronic gastroesophageal reflux disease C- Human papillomavirus infection D- Iron deficiency anemia   Q- A 66-year-old woman presents with … Read more

Repeated USMLE Questions Step 1 Review-157- Pharmacology

Q- A patient treated with cisplatin develops hearing loss. What is the mechanism of this adverse effect? A- Accumulation in cochlear hair cells B- Autoimmune inner ear inflammation C- Decreased cerebral perfusion D- Inhibition of prostaglandin synthesis   Q- A patient taking phenelzine develops severe hypertension after eating aged cheese. What is the underlying cause … Read more

Repeated USMLE Questions Step 1- Review- 156

Q- A 6-month-old infant presents with recurrent bacterial and fungal infections. Laboratory testing shows markedly decreased CD18 expression on neutrophils. Which of the following mechanisms is primarily impaired? A- Chemotaxis toward IL-8 B- Diapedesis through endothelium C- Phagolysosome fusion D- Reactive oxygen species formation   Q- A patient with chronic alcoholism develops confusion, ophthalmoplegia, and … Read more

Repeated USMLE Questions Step 1 Review-155- Pharmacology

Q- A patient treated with gentamicin develops renal impairment. What is the primary mechanism of this adverse effect? A- Accumulation in proximal tubule cells B- Acute interstitial nephritis C- Decreased renal blood flow D- Immune-mediated glomerulonephritis   Q- A patient on long-term NSAID therapy develops gastric ulcers. Which mechanism is responsible? A- Decreased leukotriene production … Read more

Repeated USMLE Questions Step 1 Review-154- Pathology

Q- A 24-year-old woman presents with neck swelling. Fine-needle aspiration of a thyroid nodule shows polygonal cells with amyloid deposits in the stroma. Which hormone is most likely elevated in this patient? A-Calcitonin B-Parathyroid hormone C-Thyroxine (T4) D-Triiodothyronine (T3)   Q- A 67-year-old man presents with sudden abdominal pain and bloody diarrhea. CT scan shows … Read more