Repeated USMLE Questions Step 1 Review- 134- Pharmacology

Q- A 25-year-old man is treated with chloramphenicol for typhoid fever. He later develops pallor, fatigue, and pancytopenia. Which adverse effect best explains this presentation? A- Dose-dependent reversible anemia B- Folate deficiency C- Irreversible aplastic anemia D- Vitamin B12 deficiency   Q- A 60-year-old woman with hypertension is prescribed hydralazine. Which adverse effect is most … Read more

Repeated USMLE Questions Step 1 Review- 133- Pathology

Q- A 55-year-old man presents with hematuria. Cystoscopy shows a papillary growth in the bladder. Histology reveals malignant transitional cells. Which of the following is the most significant risk factor for this condition? A- Chronic cystitis B- Cigarette smoking C- Cyclophosphamide therapy D- Schistosoma haematobium infection   Q- A 65-year-old man presents with progressive dyspnea … Read more

Repeated USMLE Questions Step 1 Review- 132- Pharmacology

Q- Topical benzocaine overuse can cause sudden cyanosis with normal PaO₂. Which one of the following substances can reverse this reaction? A- Atropine B- Methylene blue C- Naloxone D- Sodium bicarbonate   Q- A 32-year-old woman with a history of migraines is prescribed sumatriptan. What is its mechanism of action? A- 5-HT1B/1D receptor agonist B- … Read more

Repeated USMLE Questions Step 1 Review- 131- Pharmacology

Q- A 64-year-old man with atrial fibrillation is started on warfarin therapy. After 3 days, he develops skin necrosis. Which of the following best explains this complication? A- Direct inhibition of thrombin B- Immediate depletion of clotting factors II, VII, IX, X C- Rapid decline in protein C leading to transient hypercoagulability D- Vitamin K … Read more

Repeated USMLE Questions Step 1 Review- 130- Pathology

Q- A 55-year-old man with a long history of alcohol use presents with abdominal distension. Physical exam reveals shifting dullness and spider angiomas on the chest. His lab results are: total bilirubin 3.2 mg/dL, albumin 2.1 g/dL, and an INR of 1.9. Which of the following best explains the pathophysiology of his condition? A- Autoimmune … Read more

Repeated USMLE Questions Step 1 Review- 129- Pharmacology

Q- Which of the following best describes the mechanism of action of carvedilol in treating high blood pressure? A- Calcium channel blocker in vascular smooth muscle B- Central α₂-adrenergic stimulation C- Nonselective β-adrenergic blockade with α₁-adrenergic blockade D- Selective β₁-adrenergic blockade only   Q- Which of the following best describes the mechanism of action of … Read more