A 32-year-old woman with a long history of irregular menstrual periods visits her physician for consultation. She is married for 8 years and has been unable to conceive. Her menstrual period occurs once every 2-4 months. She had normal Pap smear last year. Her height is 5.2″. Her weight is 205 pounds. Her vital signs are within normal limits. She has acne and excessive facial hair.
This patient is at risk of which one of the following diseases?
A- Lung cancer
B- Cervical cancer
C- Ovarian cancer
D- Endometrial cancer
E- Liver cirrhosis
Answer
This patient is most likely has polycystic ovarian syndrome (PCOS) which is characterized by infertility, oligomenorrhea, obesity and hirsutism. Lack of menstrual cycles due to failure of ovulation leads to low level of progesterone and unopposed estrogen. Prolonged exposure of unopposed estrogen put this woman at high risk of endometrial cancer.
The correct answer is D
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