Repeated USMLE Questions Step 1- Review- 156

Q- A 6-month-old infant presents with recurrent bacterial and fungal infections. Laboratory testing shows markedly decreased CD18 expression on neutrophils. Which of the following mechanisms is primarily impaired? A- Chemotaxis toward IL-8 B- Diapedesis through endothelium C- Phagolysosome fusion D- Reactive oxygen species formation   Q- A patient with chronic alcoholism develops confusion, ophthalmoplegia, and … Read more

Repeated USMLE Questions Step 2 CK- Review- 51

Q- A 30-year-old woman presents with chronic diarrhea, bloating, and weight loss. Laboratory testing reveals iron deficiency anemia. Symptoms improve on a gluten-free diet. Which of the following antibodies is most specific for this condition? A- Anti-centromere antibodies B- Anti-dsDNA antibodies C- Anti-endomysial antibodies D- Anti-mitochondrial antibodies   Q- A 58-year-old man presents with progressive … Read more

Repeated USMLE Questions Step 1 Review-155- Pharmacology

Q- A patient treated with gentamicin develops renal impairment. What is the primary mechanism of this adverse effect? A- Accumulation in proximal tubule cells B- Acute interstitial nephritis C- Decreased renal blood flow D- Immune-mediated glomerulonephritis   Q- A patient on long-term NSAID therapy develops gastric ulcers. Which mechanism is responsible? A- Decreased leukotriene production … Read more

Repeated USMLE Questions Step 1 Review-154- Pathology

Q- A 24-year-old woman presents with neck swelling. Fine-needle aspiration of a thyroid nodule shows polygonal cells with amyloid deposits in the stroma. Which hormone is most likely elevated in this patient? A-Calcitonin B-Parathyroid hormone C-Thyroxine (T4) D-Triiodothyronine (T3)   Q- A 67-year-old man presents with sudden abdominal pain and bloody diarrhea. CT scan shows … Read more

Repeated USMLE Questions Step 2 CK- Review- 50

Q- A 5-year-old boy presents with generalized edema and frothy urine. Urinalysis shows proteinuria (+++), but no hematuria. Serum albumin is low, and cholesterol is elevated. What is the most likely diagnosis? A- Acute poststreptococcal glomerulonephritis B- IgA nephropathy C- Membranous nephropathy D- Minimal change disease   Q- A 28-year-old woman presents with acute shortness … Read more

Repeated USMLE Questions Step 1 Review-153- Pharmacology

Q- Which of the following antifungal medications inhibits ergosterol synthesis by blocking fungal cytochrome P450 enzymes? A- Amphotericin B B- Fluconazole C- Flucytosine D- Terbinafine   Q- A 29-year-old woman treated with lithium presents with tremor, polyuria, and confusion. Which laboratory finding is most likely present? A- Hypercalcemia B- Hypoglycemia C- Hypokalemia D- Hyponatremia   … Read more