A 24 year old medical student visits her physician for a refill of her treatment of depression. She is prescribed imipramine, a tricyclic antidepressant. During discussion of the treatment, her physician mentions that this drug undergoes first pass hepatic metabolism.
The prescribed drug is most likely administered by which route?
Drugs administered by oral route are the first drugs to reach portal hepatic circulation. They undergo first pass metabolism and they are bio transformed before they reach systemic circulation. The net result is either reduction or activation of the drug depending on the properties of each drug. Imipramine is methylated by hepatic enzymes and converted to an active metabolite.
Drugs administered by intramuscular, intravenous, subcutaneous and sublingual routes reach the blood stream first before they are metabolized by liver enzymes.
The correct answer is C
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C . Oral route
Due to enterohepatic circulation
Thank you DrManzoor
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