Question of the Day 2





A 24 year old medical student visits her physician for a refill of her treatment of depression. She is prescribed imipramine, a tricyclic antidepressant. During discussion of the treatment, her physician mentions that this drug undergoes first pass hepatic metabolism.

The prescribed drug is most likely administered by which route?

A-Intramuscular

B-Intravenous

C-Oral

D-Subcutaneous

E-Sublingual





Answer

Drugs administered by oral route are the first drugs to reach portal hepatic circulation. They undergo first pass metabolism and they are bio transformed before they reach systemic circulation. The net result is either reduction or activation of the drug depending on the properties of each drug. Imipramine is methylated by hepatic enzymes and converted to an active metabolite.

Drugs administered by intramuscular, intravenous, subcutaneous and sublingual routes reach the blood stream first before they are metabolized by liver enzymes.

The correct answer is C


24 thoughts on “Question of the Day 2”

  1. Thank you all for your great answers. We have 13 answers, 12 are correct. Great job.
    After drawing, the winner is bincey. The book will be sent to your email.
    Congratulations and have a good luck tomorrow for another question of the day.
    Thank you

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