Q- Which one of the following medications enters the cell and acts on a cytoplasmic receptor?
A- Adrenaline
B- Dexamethasone
C- Insulin
D- Propranolol
B-Dexamethasone- It is the only one of the listed medications that combines with a cytoplasmic receptor, enters the nucleus and alters gene expression. Other medications act on membranous receptors.
Q- Which one of the following local anesthetics causes local vasoconstriction and may lead to hypertension?
A- Cocaine
B- Etidocaine
C- Lidocaine
D- Tetracaine
A-Cocaine- It acts by inhibiting reuptake of norepinephrine through sympathetic nerve endings. Other local anesthetics on the list cause vasodilation.
Q- Which one of the following drugs is the first-line medication in transplant immunopharmacology?
A- Cyclosporine
B- Methotrexate
C- Sulfasalazine
D- Thalidomide
A-Cyclosporine- Methotrexate and sulfasalazine are used in the treatment of rheumatoid arthritis and some cancers. Thalidomide is used in erythema nodosum leprosum and multiple myeloma.
