Repeated USMLE Questions Step 1- Pharmacology- 307

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Q- Loop diuretics act by inhibition of the Na/K/Cl cotransporter on the luminal membrane of which one of the following locations?

A- Ascending loop of Henle

B- Collecting tubules

C- Descending loop of Henle

D- Proximal convoluted tubules

A- Ascending loop of Henle- Furosemide and other loop diuretics inhibit this cotransporter leading to diuresis and loss of Na, Cl and K in urine. 



Q- Which one of the following anti-hypertensive medications acts mainly through lowering the peripheral resistance by direct arteriolar vasodilation?

A- Atenolol

B- Hydralazine

C- Lisinopril

D- Losartan

B- Hydralazine- It is one of the direct-acting vasodilators which also include nitroprusside, minoxidil and diazoxide. 



Q- Which one of the following peptic ulcer treatments is a PGE1 analog and acts as a cytoprotective by increasing mucus and bicarbonate secretion and lowering acid secretion?

A- Cimetidine

B- Misoprostol

C- Omeprazole

D- Sucralfate

B- Misoprostol- It was used previously but now proton pump inhibitors are preferred for peptic ulcer treatment. 



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10 thoughts on “Repeated USMLE Questions Step 1- Pharmacology- 307”

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