Q- In a peptic ulcer patient, which one of the following medications acts through reversible block of histamine H2-receptors?
A-Misoprostol
B-Omeprazole
C-Ranitidine
D-Sucralfate
C-Ranitidine- It is the only one on the list that is histamine H2-blocker. Misoprostol is a PGE1 analog. Omeprazole is H/K ATPase inhibitor and Sucralfate binds to ulcer to provide physical protection. This is a very important topic in USMLE.
Q- Which one of the following anti-coagulant medications may cause drug-induced thrombocytopenia?
A-Bivalirudin
B-Heparin
C-Streptokinase
D-Warfarin
B-Heparin- DIT is caused by development of IgG antibodies against heparin forming a complex that activates platelets leading to thrombosis and thrombocytopenia.
Q- Which one of the following medications is used to prevent cardiotoxicity caused by doxorubicin chemotherapy?
A-Dexrazoxane
B-Leucovorin
C-Mensa
D-Topotecan
A-Dexrazoxane- It is an iron chelating agent used to prevent dilated cardiomyopathy caused by doxorubicin.
