Q- Myalgia and rhabdomyolysis may follow the use of which one of the following drug groups?
A- Beta blockers
B- Calcium channel blockers
C- Loop diuretics
D- Statins
D- Statins-This group of drugs which include atorvastatin and simvastatin can cause muscle pain, aches and damage. Rarely, it can cause rhabdomyolysis which can lead to renal failure due to accumulation of metabolites.
Q- Sildenafil is used in the treatment of erectile dysfunction through inhibition of which one of the following phosphodiesterase isoenzymes?
A- PDE2
B- PDE3
C- PDE4
D- PDE5
D- PDE5- Inhibition of this isoenzyme leads to accumulation of cyclic GMP which leads to vasodilation and erection.
Q- Which one of the following drugs is the first choice in the treatment of beta blocker overdose?
A- Albuterol
B- Flumazenil
C- Glucagon
D- Prednisone
C- Glucagon- It leads to increased cardiac contractions and decreased renal vascular resistance.
