USMLE Q Bank Step 1- 207

A 65 year old man presents to the clinic complaining of weakness and recurrent infections for 6 months. He has no significant medical, surgical or family history. Physical examination reveals multiple enlarged lymph nodes. Histopathology reveals excessive mature B cells that mark strongly with CD5 and CD23 and weekly with CD22. They also have weak expression of kappa chains on the plasma membrane.

What is the most likely diagnosis?

A- Acute lymphatic leukemia

B- Chronic lymphocytic leukemia

C- Chronic myeloid leukemia

D- Hairy cell leukemia

E- Sezary syndrome


This is a typical case of chronic lymphocytic leukemia. Other leukemias have strong expression of CD22.

The correct answer is B

1 thought on “USMLE Q Bank Step 1- 207”

  1. B

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