Repeated USMLE Questions Step 1 Review-158- Pathology

Q- A 59-year-old man presents with progressive dysphagia. Endoscopy reveals an ulcerated mass in the distal esophagus. Biopsy shows malignant gland-forming cells. Which risk factor is most strongly associated with this condition? A- Alcohol consumption B- Chronic gastroesophageal reflux disease C- Human papillomavirus infection D- Iron deficiency anemia   Q- A 66-year-old woman presents with … Read more

Repeated USMLE Questions Step 2 CK- Review- 52

Q- A 67-year-old man presents with sudden onset left arm weakness and facial droop that resolved completely within 30 minutes. CT scan of the head is normal. What is the most likely diagnosis? A- Intracerebral hemorrhage B- Ischemic stroke C- Subarachnoid hemorrhage D- Transient ischemic attack   Q- A 34-year-old woman presents with heat intolerance, … Read more

Repeated USMLE Questions Step 1 Review-157- Pharmacology

Q- A patient treated with cisplatin develops hearing loss. What is the mechanism of this adverse effect? A- Accumulation in cochlear hair cells B- Autoimmune inner ear inflammation C- Decreased cerebral perfusion D- Inhibition of prostaglandin synthesis   Q- A patient taking phenelzine develops severe hypertension after eating aged cheese. What is the underlying cause … Read more

Repeated USMLE Questions Step 1- Review- 156

Q- A 6-month-old infant presents with recurrent bacterial and fungal infections. Laboratory testing shows markedly decreased CD18 expression on neutrophils. Which of the following mechanisms is primarily impaired? A- Chemotaxis toward IL-8 B- Diapedesis through endothelium C- Phagolysosome fusion D- Reactive oxygen species formation   Q- A patient with chronic alcoholism develops confusion, ophthalmoplegia, and … Read more

Repeated USMLE Questions Step 2 CK- Review- 51

Q- A 30-year-old woman presents with chronic diarrhea, bloating, and weight loss. Laboratory testing reveals iron deficiency anemia. Symptoms improve on a gluten-free diet. Which of the following antibodies is most specific for this condition? A- Anti-centromere antibodies B- Anti-dsDNA antibodies C- Anti-endomysial antibodies D- Anti-mitochondrial antibodies   Q- A 58-year-old man presents with progressive … Read more

Repeated USMLE Questions Step 1 Review-155- Pharmacology

Q- A patient treated with gentamicin develops renal impairment. What is the primary mechanism of this adverse effect? A- Accumulation in proximal tubule cells B- Acute interstitial nephritis C- Decreased renal blood flow D- Immune-mediated glomerulonephritis   Q- A patient on long-term NSAID therapy develops gastric ulcers. Which mechanism is responsible? A- Decreased leukotriene production … Read more