Repeated USMLE Questions Step 1 Review-170- Pathology

Q- A 27-year-old woman presents with a painless thyroid nodule. Biopsy shows tumor cells forming follicles but without the nuclear features of papillary carcinoma. Capsular invasion is present. What is the most likely diagnosis? A- Anaplastic thyroid carcinoma B- Follicular thyroid carcinoma C- Medullary thyroid carcinoma D- Papillary thyroid carcinoma   Q- A 50-year-old man … Read more

Repeated USMLE Questions Step 2 CK- Review- 58

Q- A 32-year-old woman presents with fatigue and pruritus. Labs show elevated alkaline phosphatase and positive anti–mitochondrial antibodies. What is the most appropriate initial treatment? A- Azathioprine B- Prednisone C- Ursodeoxycholic acid D- Vitamin K   Q- A 70-year-old hospitalized patient suddenly develops dyspnea and hypotension. CT angiography confirms a massive pulmonary embolism. What is … Read more

Repeated USMLE Questions Step 1 Review-169- Pharmacology

Q- A patient receiving trimethoprim-sulfamethoxazole develops megaloblastic anemia. Which mechanism explains this adverse effect? A- Folate metabolism inhibition B- Hemoglobin oxidation C- Inhibition of erythropoietin synthesis D- Vitamin B12 malabsorption   Q- A patient with hypertension is treated with clonidine. What is the primary mechanism by which this drug lowers blood pressure? A- Alpha-1 receptor … Read more

Repeated USMLE Questions Step 1- Review-168

Q- A 6-month-old infant presents with developmental delay, hypotonia, and a cherry-red spot on retinal examination. There is no hepatosplenomegaly. Which enzyme deficiency is most likely responsible for this condition? A- Arylsulfatase A B- β-Hexosaminidase A C- Glucocerebrosidase D- Sphingomyelinase   Q- A researcher is studying oxygen delivery in tissues. Which factor shifts the oxyhemoglobin … Read more

Repeated USMLE Questions Step 2 CK- Review- 57

Q- A 45-year-old woman presents with fever and a productive cough. She has been started on antibiotics for community-acquired pneumonia. Two days later, she develops profuse watery diarrhea. The stool test is positive for toxin. What is the most appropriate treatment? A-Ciprofloxacin B-Loperamide C-Oral vancomycin D-Stop antibiotics only   Q- A 72-year-old woman presents with … Read more

Repeated USMLE Questions Step 1 Review-167- Pharmacology

Q- A patient treated with vancomycin develops acute kidney injury. Which concurrent medication increases this risk most significantly? A- Amoxicillin B- Azithromycin C- Gentamicin D- Metronidazole   Q- A patient who is taking a high dose of niacin for hyperlipidemia develops hyperglycemia. What explains this effect? A- Decreased insulin secretion B- Decreased peripheral glucose uptake … Read more