Repeated USMLE Questions Step 1 Review-181- Pharmacology

Q– A patient with heart failure is prescribed a drug that inhibits the Na⁺/K⁺-ATPase pump, increasing intracellular calcium in cardiac myocytes. Which one of the following drugs is most likely responsible? A- Amiodarone B- Digoxin C- Diltiazem D- Verapamil Correct Answer B- Digoxin- Digoxin inhibits the Na⁺/K⁺-ATPase pump, increasing intracellular sodium. This reduces Na⁺/Ca²⁺ exchange, … Read more

Repeated USMLE Questions Step 1- Review-180

Q- A patient is prescribed heparin. Which one of the following laboratory tests is used to monitor its effectiveness? A- Bleeding time B- International normalized ratio (INR) C- Platelet count D- Partial thromboplastin time (PTT)   Q- Which one of the following types of lung cancer could be accompanied by Horner’s syndrome? A- Adenocarcinoma of … Read more

Repeated USMLE Questions Step 1 Review-179- Pharmacology

Q- A patient treated with amoxicillin develops a rash after taking the medication. What type of reaction is most likely? A- Type I hypersensitivity B- Type II hypersensitivity C- Type III hypersensitivity D- Type IV hypersensitivity   Q- A patient taking NSAIDs develops decreased kidney function. What is the mechanism of this effect? A- Decreased … Read more

Repeated USMLE Questions Step 1 Review-177- Pharmacology

Q- A patient treated with tacrolimus after kidney transplantation develops nephrotoxicity. What is the primary molecular mechanism of tacrolimus? A- Blocks IL-2 transcription by inhibiting calcineurin B- Inhibits dihydrofolate reductase C- Inhibits inosine monophosphate dehydrogenase D- Stimulates T-cell apoptosis directly   Q- A patient with chronic angina is treated with ranolazine. What is the primary … Read more

Repeated USMLE Questions Step 1- Review-176

Q- A drug that increases GABA activity in the central nervous system is prescribed for anxiety. Which class of drugs acts by increasing the frequency of chloride channel opening at the GABA-A receptor? A- Barbiturates B- Benzodiazepines C- Selective serotonin reuptake inhibitors D- Tricyclic antidepressants   Q- A woman has heavy menstrual bleeding and prolonged … Read more

Repeated USMLE Questions Step 1 Review-175- Pharmacology

Q- A patient with atrial fibrillation is treated with dofetilide. Which electrophysiologic effect explains the antiarrhythmic action of this drug? A- Decreased phase 0 depolarization B- Increased refractory period by potassium channel blockade C- Inhibition of calcium influx in AV node D- Sodium channel blockade during depolarization   Q- A patient treated with acetazolamide develops … Read more