Repeated USMLE Questions Step 1 Review-179- Pharmacology

Q- A patient treated with amoxicillin develops a rash after taking the medication. What type of reaction is most likely? A- Type I hypersensitivity B- Type II hypersensitivity C- Type III hypersensitivity D- Type IV hypersensitivity   Q- A patient taking NSAIDs develops decreased kidney function. What is the mechanism of this effect? A- Decreased … Read more

Repeated USMLE Questions Step 1 Review-178- Pathology

Q- A 45-year-old man presents with epigastric pain that improves with eating. Endoscopy reveals a duodenal ulcer. Which organism is most commonly responsible for this condition? A- Campylobacter jejuni B- Clostridioides difficile C- Helicobacter pylori D- Vibrio cholerae   Q- A 70-year-old man presents with progressive difficulty initiating urination and a weak urinary stream. Biopsy … Read more

Repeated USMLE Questions Step 1 Review-177- Pharmacology

Q- A patient treated with tacrolimus after kidney transplantation develops nephrotoxicity. What is the primary molecular mechanism of tacrolimus? A- Blocks IL-2 transcription by inhibiting calcineurin B- Inhibits dihydrofolate reductase C- Inhibits inosine monophosphate dehydrogenase D- Stimulates T-cell apoptosis directly   Q- A patient with chronic angina is treated with ranolazine. What is the primary … Read more

Repeated USMLE Questions Step 1- Review-176

Q- A drug that increases GABA activity in the central nervous system is prescribed for anxiety. Which class of drugs acts by increasing the frequency of chloride channel opening at the GABA-A receptor? A- Barbiturates B- Benzodiazepines C- Selective serotonin reuptake inhibitors D- Tricyclic antidepressants   Q- A woman has heavy menstrual bleeding and prolonged … Read more

Repeated USMLE Questions Step 1 Review-175- Pharmacology

Q- A patient with atrial fibrillation is treated with dofetilide. Which electrophysiologic effect explains the antiarrhythmic action of this drug? A- Decreased phase 0 depolarization B- Increased refractory period by potassium channel blockade C- Inhibition of calcium influx in AV node D- Sodium channel blockade during depolarization   Q- A patient treated with acetazolamide develops … Read more

Repeated USMLE Questions Step 1 Review-174- Pathology

Q- A 64-year-old man with a long history of smoking presents with hematuria. Cystoscopy reveals a papillary tumor arising from the bladder mucosa. Which molecular alteration is most commonly associated with low-grade papillary urothelial carcinoma? A- KRAS mutation B- FGFR3 mutation C- BRAF mutation D- APC mutation   Q- A 14-year-old boy presents with a … Read more