Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Step 1 practice questions with answers: how nitrates reduce preload, the metabolic markers of vitamin B12 deficiency, and maternal inheritance of mitochondrial DNA.
Step 1 practice questions with answers: monitoring heparin with PTT, Pancoast tumor and Horner syndrome, and vitamin B12 deficiency megaloblastic anemia.
Step 1 practice questions with answers: how benzodiazepines enhance GABA, bleeding in von Willebrand disease, and the enzyme deficient in classic galactosemia.
Step 1 practice questions with answers: pancreatic insufficiency in cystic fibrosis, the thymus in myasthenia gravis, and the neural crest origin of pheochromocytoma.
Step 1 practice questions with answers: the enzyme deficient in Tay-Sachs disease, causes of a right shift in the oxygen dissociation curve, and PTH action on the kidney.
Five Step 1 questions with answers: NADPH oxidase in chronic granulomatous disease, polymyositis, Graves disease antibodies, Alport syndrome, and omeprazole.