Free Questions and Answers for All Medical Students all over the World
Start here: practice all 95 questions on one page in our USMLE Pathology Question Bank, organized by system.
Pathology is the backbone of USMLE Step 1: almost every clinical vignette asks you to connect a disease with its mechanism, histology or lab findings. This page collects all of our pathology practice questions in one place.
High-yield pathology topics to master
• Neoplasia – tumor markers, translocations such as t(15;17), and classic tumors like osteosarcoma and small cell carcinoma.
• Hematopathology – anemias, myelofibrosis, multiple myeloma and leukemias.
• Renal pathology – nephritic vs nephrotic syndromes, diabetic nephropathy and crescentic glomerulonephritis.
• GI and liver – H. pylori, Crohn disease, cirrhosis and obstructive jaundice.
• Classic histology – Congo red amyloid, zellballen, caseating granulomas and neurofibrillary tangles.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
I am going to answer the sample USMLE Step 1 Questions with Explanation. These questions are available at USMLE.org A 26-year-old man comes to the office because of a 1-week history of increased urinary frequency accompanied by excessive thirst. He says he has been urinating hourly. Physical examination shows no abnormalities. Serum chemistry studies are … Read more
I am going to answer the sample USMLE Step 1 Questions with Explanation. These questions are available at USMLE.org Q- A 51-year-old man with a 10-year history of gastroesophageal reflux and suspected Barrett esophagus comes to the office because his omeprazole dose “doesn’t work around the Christmas holidays.” He states that he prides himself on … Read more
Q- Which one of the following medications may cause metabolic acidosis by reducing the reabsorption of bicarbonate in the kidneys? A- Acetazolamide B- Furosemide C- Hydrochlorothiazide D- Spironolactone Q- Chancroid is a sexually transmitted infection (STI) characterized by painful ulcers on the genitalia. This infection is caused by which one of the following organisms? A- … Read more
Q- Gaucher disease is a genetic disorder that may cause hepatomegaly and splenomegaly. It is caused by a deficiency of which one of the following enzymes? A- Alpha-galactosidase B- Glucocerebrosidase C- Hexosaminidase A D- Sphingomyelinase Q- Which one of the following is the most effective treatment for a case of Fabry disease? A- Antibiotic therapy … Read more
Q- Which one of the following drugs is a calcium channel blocker (Class IV)? A- Amiodarone B- Carvedilol C- Procainamide D- Verapamil Q- Which one of the following cells secretes glycosaminoglycan and is found in the terminal and respiratory bronchioles? A- Clara cells B- K cells C- Macrophages D- Pneumocytes type Q- Which one … Read more
Q- In which one of the following locations a mural thrombus commonly occurs following myocardial infarction? A- Left atrium B- Left ventricle C- Right atrium D- Right ventricle E- Thoracic aorta Q- Bones of calvarium and facial bones are formed by which one of the following types of ossification? A- Endochondral ossification B- Membranous ossification … Read more