USMLE Pathology Questions

Start here: practice all 95 questions on one page in our USMLE Pathology Question Bank, organized by system.

Pathology is the backbone of USMLE Step 1: almost every clinical vignette asks you to connect a disease with its mechanism, histology or lab findings. This page collects all of our pathology practice questions in one place.

High-yield pathology topics to master
• Neoplasia – tumor markers, translocations such as t(15;17), and classic tumors like osteosarcoma and small cell carcinoma.
• Hematopathology – anemias, myelofibrosis, multiple myeloma and leukemias.
• Renal pathology – nephritic vs nephrotic syndromes, diabetic nephropathy and crescentic glomerulonephritis.
• GI and liver – H. pylori, Crohn disease, cirrhosis and obstructive jaundice.
• Classic histology – Congo red amyloid, zellballen, caseating granulomas and neurofibrillary tangles.

Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.

Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.