Repeated USMLE Questions Step 1 Review-164- Pathology

Q- A 45-year-old woman presents with episodic headaches, sweating, and palpitations. Imaging reveals an adrenal medullary tumor. Which histologic pattern is most characteristic of this tumor? A- Keratin pearls B- Psammoma bodies C- Sheets of small blue cells D- Zellballen pattern   Q- A 63-year-old man with long-standing diabetes presents with progressive renal failure. Renal … Read more

Repeated USMLE Questions Step 1- Review-162

Q- A 2-year-old child has recurrent infections with catalase-positive organisms. Neutrophils show absent oxidative burst on flow cytometry. Which enzyme is defective? A- Adenosine deaminase B- Glucose-6-phosphate dehydrogenase C- NADPH oxidase D- Myeloperoxidase   Q- A patient has difficulty rising from a chair and climbing stairs. Biopsy shows endomysial inflammation and CD8+ T-cell infiltration. Which … Read more

Repeated USMLE Questions Step 1 Review-158- Pathology

Q- A 59-year-old man presents with progressive dysphagia. Endoscopy reveals an ulcerated mass in the distal esophagus. Biopsy shows malignant gland-forming cells. Which risk factor is most strongly associated with this condition? A- Alcohol consumption B- Chronic gastroesophageal reflux disease C- Human papillomavirus infection D- Iron deficiency anemia   Q- A 66-year-old woman presents with … Read more

Repeated USMLE Questions Step 1- Review- 156

Q- A 6-month-old infant presents with recurrent bacterial and fungal infections. Laboratory testing shows markedly decreased CD18 expression on neutrophils. Which of the following mechanisms is primarily impaired? A- Chemotaxis toward IL-8 B- Diapedesis through endothelium C- Phagolysosome fusion D- Reactive oxygen species formation   Q- A patient with chronic alcoholism develops confusion, ophthalmoplegia, and … Read more

Repeated USMLE Questions Step 1 Review-154- Pathology

Q- A 24-year-old woman presents with neck swelling. Fine-needle aspiration of a thyroid nodule shows polygonal cells with amyloid deposits in the stroma. Which hormone is most likely elevated in this patient? A-Calcitonin B-Parathyroid hormone C-Thyroxine (T4) D-Triiodothyronine (T3)   Q- A 67-year-old man presents with sudden abdominal pain and bloody diarrhea. CT scan shows … Read more

Repeated USMLE Questions Step 1- Review- 152

Q- A 65-year-old man with heart failure is started on spironolactone. Which adverse effect should be monitored most closely? A- Gynecomastia B- Hypocalcemia C- Hypokalemia D- Metabolic acidosis   Q- A 60-year-old man presents with weakness, fatigue, and splenomegaly. His complete blood count shows pancytopenia. Bone marrow aspiration is “dry,” but biopsy shows fibrotic marrow … Read more