Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Five Step 1 pharmacology questions with answers: amphotericin B toxicity, digoxin toxicity, drug-induced lupus, misoprostol, and abrupt steroid withdrawal.
Five Step 1 questions with answers: vitamin D in chronic kidney disease, smooth muscle contraction, TAP transporter defects, irreversible enzyme inhibitors, and oxidative phosphorylation.
Five Step 1 questions with answers: CD18 and leukocyte adhesion, thiamine deficiency enzymes, use-dependent sodium channel blockers, 21-hydroxylase deficiency, and G protein signaling.
Step 1 practice questions with answers: gynecomastia from spironolactone, bone marrow fibrosis in myelofibrosis, and ondansetron as a 5-HT3 antagonist.
Step 1 practice questions with answers: the WASP gene in Wiskott-Aldrich syndrome, the continuous murmur of patent ductus arteriosus, and Graves disease antibodies.
Step 1 practice questions with answers: buprenorphine as a partial opioid agonist, hyaline arteriosclerosis in hypertension, and phagolysosome defects in Chédiak-Higashi syndrome.