Q- A patient treated with tacrolimus after kidney transplantation develops nephrotoxicity. What is the primary molecular mechanism of tacrolimus?
A- Blocks IL-2 transcription by inhibiting calcineurin
B- Inhibits dihydrofolate reductase
C- Inhibits inosine monophosphate dehydrogenase
D- Stimulates T-cell apoptosis directly
Q- A patient with chronic angina is treated with ranolazine. What is the primary mechanism responsible for its antianginal effect?
A- Decreased heart rate via beta blockade
B- Inhibition of late sodium current in cardiac cells
C- Increased coronary artery dilation
D- Stimulation of nitric oxide release
Q- A patient treated with mycophenolate mofetil develops leukopenia. What is the primary molecular target of this drug?
A- Dihydrofolate reductase
B- Inosine monophosphate dehydrogenase
C- Thymidylate synthase
D- Xanthine oxidase
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