Repeated USMLE Questions Step 1- Review-176

Q- A drug that increases GABA activity in the central nervous system is prescribed for anxiety. Which class of drugs acts by increasing the frequency of chloride channel opening at the GABA-A receptor? A- Barbiturates B- Benzodiazepines C- Selective serotonin reuptake inhibitors D- Tricyclic antidepressants   Q- A woman has heavy menstrual bleeding and prolonged … Read more

Repeated USMLE Questions Step 1 Review-174- Pathology

Q- A 64-year-old man with a long history of smoking presents with hematuria. Cystoscopy reveals a papillary tumor arising from the bladder mucosa. Which molecular alteration is most commonly associated with low-grade papillary urothelial carcinoma? A- KRAS mutation B- FGFR3 mutation C- BRAF mutation D- APC mutation   Q- A 14-year-old boy presents with a … Read more

Repeated USMLE Questions Step 1- Review-172

Q- A child has chronic diarrhea and failure to thrive. Stool is positive for fat. The sweat chloride test is elevated. Which mechanism explains the GI symptoms? A- Decreased pancreatic enzyme secretion B- Increased bile acid synthesis C- Increased gastric acid production D- Increased intestinal chloride secretion   Q- A patient has progressive weakness and … Read more

Repeated USMLE Questions Step 1 Review-170- Pathology

Q- A 27-year-old woman presents with a painless thyroid nodule. Biopsy shows tumor cells forming follicles but without the nuclear features of papillary carcinoma. Capsular invasion is present. What is the most likely diagnosis? A- Anaplastic thyroid carcinoma B- Follicular thyroid carcinoma C- Medullary thyroid carcinoma D- Papillary thyroid carcinoma   Q- A 50-year-old man … Read more

Repeated USMLE Questions Step 1 Review-166- Pathology

Q- A 34-year-old woman presents with chronic diarrhea and abdominal pain. Colonoscopy reveals transmural inflammation with skip lesions. Which complication is most likely in this condition? A- Toxic megacolon B- Colorectal adenocarcinoma C- Fistula formation D- Primary sclerosing cholangitis   Q- A 58-year-old man presents with fatigue and easy bruising. Peripheral smear shows blasts with … Read more

Repeated USMLE Questions Step 1 Review-164- Pathology

Q- A 45-year-old woman presents with episodic headaches, sweating, and palpitations. Imaging reveals an adrenal medullary tumor. Which histologic pattern is most characteristic of this tumor? A- Keratin pearls B- Psammoma bodies C- Sheets of small blue cells D- Zellballen pattern   Q- A 63-year-old man with long-standing diabetes presents with progressive renal failure. Renal … Read more