Q- Which one of the following parts of the fallopian tube is the widest and the most common site for fertilization?
A- Ampulla
B- Infundibulum
C- Isthmus
A- Ampulla- The ampulla is the widest portion of the fallopian tube and is the most common site of fertilization. The infundibulum and isthmus are narrower and less commonly involved in fertilization.
Q- Coagulation factor VIII is produced by which of the following cells?
A- Endothelial cells
B- Hepatic cells
C- Juxtaglomerular cells
D- Splenic macrophages
A- Endothelial cells- Coagulation factor VIII is produced primarily by endothelial cells, especially in the liver and elsewhere in the vascular system. Hepatocytes do not synthesize factor VIII. Juxtaglomerular cells and splenic macrophages play no role in its production.
Q- Which one of the following substances induces the closure of the patent ductus arteriosus?
A- Estradiol
B- Ibuprofen
C- Indomethacin
D- Prostaglandin E
C- Indomethacin- Indomethacin promotes closure of a patent ductus arteriosus by inhibiting prostaglandin synthesis. Prostaglandin E keeps the ductus open, and ibuprofen can also help but indomethacin is the classic and most effective choice.
Hi Dr. Waseem, can you please send me the quote or screen shot of that. Thank you
Hello ! Ibuprofen is better answer than indomethacin acc to Goodman and gillman pharma
Well, both of them need to be taken with food. Indomethacin is used to induce the closure of patent ductus arteriosus. Thank you for your comment.
Sir my Pharma and Pediatrics teachers taught in Ibuprofen is more preferred over indomethacin because of risk of perforation by usage of indomethacin
Correct. Thank you Dr. Deeptha for this information.
Except clotting factor III,IV,VIII other factors are synthesized by the liver.
Ibuprofen has no role in PDA closure. If you read it in any book, please let me know. Thank you Dr. Ana.
Hello. in the question regarding the PDA, wouldn’t ibuprofen also be a correct answer?
Thank you Dr. Zetun
Thank you .
Thank you Dr Kennedy. Good luck in your boards.
Very helpful
Thank you
Good
Hi