Q- Thyroid hormone can cause which one of the following effects?
A- Hypoglycemia
B- Lowers blood cholesterol
C- Lowers body temperature
D- Lowers oxygen consumption
B- Lowers blood cholesterol- Thyroid hormone act on the nucleus and altering the rate of gene expression. It causes increase in oxygen consumption, decreased blood cholesterol levels, hyperglycemia and thermogenesis.
Q- Which one of the following enzymes is associated with Lyesh-Nyhan syndrome?
B- Hypoxanthine-guanine phosphoribosyl transferase- This enzyme is a part of the salvage pathway for purines. A deficiency leads to inability to recycle purines which results in overproduction of uric acid. Individuals with Lesch-Nyhan syndrome are mentally retarded.
Q- Pemphigus is an autoimmune skin disease associated with which of the following structures? ,
A- Cell matrix junctions
B- Desmosomes
C- Gap junctions
D- Tight junctions
B- Desmosomes- Pemphigus is caused by autoantibodies against the transmembrane glycoproteins. These antibodies bind to proteins and disrupt the desmosomes.
