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Repeated USMLE Questions Step 1- 173




Gluconeogenesis is a metabolic process in which glucose is generated from non-carbohydrate carbon substrates.

Which one of the following substrates does NOT share its carbon in glucose skeleton but rather contributes as an energy source for gluconeogenesis?

A- Acetyl CoA

B- Alpha-ketoglutarate

C- Fumarate

D- Oxaloacetate

E- Succinyl CoA

Answer




Acetyl CoA is an energy source as it generates 12 ATP for each citric acid cycle. Other substrates contribute their carbon in glucose skeleton.

The correct answer is A







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