Repeated USMLE Questions Step 1 Review-154- Pathology

Q- A 24-year-old woman presents with neck swelling. Fine-needle aspiration of a thyroid nodule shows polygonal cells with amyloid deposits in the stroma.
Which hormone is most likely elevated in this patient?

A-Calcitonin

B-Parathyroid hormone

C-Thyroxine (T4)

D-Triiodothyronine (T3)

A-Calcitonin- Medullary carcinoma of the thyroid arises from parafollicular C cells and produces calcitonin. Amyloid deposition is due to calcitonin accumulation.

 

Q- A 67-year-old man presents with sudden abdominal pain and bloody diarrhea. CT scan shows thickening of the colon at the splenic flexure.
Which vascular pathology best explains this finding?

A-Ischemic colitis due to watershed infarction

B-Mesenteric venous congestion

C-Portal vein thrombosis

D-Ulcerative colitis

B-Ischemic colitis due to watershed infarction- The splenic flexure is a watershed area between SMA and IMA territories, making it vulnerable to ischemia during hypoperfusion.

 

Q- A 55-year-old man with chronic alcoholism presents with ascites and spider angiomas. Liver biopsy shows regenerative nodules surrounded by fibrous septa.
What is the underlying pathological process?

A-Acute hepatitis

B-Cirrhosis

C-Fatty liver disease

D-Hepatocellular carcinoma

B-Cirrhosis- Cirrhosis is characterized by diffuse fibrosis and regenerative nodules, leading to portal hypertension and liver dysfunction.

 

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