Repeated USMLE Questions Step 1 Review-170- Pathology

Q- A 27-year-old woman presents with a painless thyroid nodule. Biopsy shows tumor cells forming follicles but without the nuclear features of papillary carcinoma. Capsular invasion is present.
What is the most likely diagnosis?

A- Anaplastic thyroid carcinoma

B- Follicular thyroid carcinoma

C- Medullary thyroid carcinoma

D- Papillary thyroid carcinoma

B- Follicular thyroid carcinoma- Follicular carcinoma is diagnosed by capsular or vascular invasion and lacks the nuclear features seen in papillary carcinoma.

 

Q- A 50-year-old man presents with progressive muscle weakness and fatigue. Imaging reveals a mediastinal mass.
Which autoimmune disease is most commonly associated with this tumor?

A- Multiple sclerosis

B- Myasthenia gravis

C- Rheumatoid arthritis

D- Systemic lupus erythematosus

B- Myasthenia gravis- Thymomas are frequently associated with myasthenia gravis due to autoantibodies against acetylcholine receptors.

 

Q- A 65-year-old woman presents with progressive back pain. X-ray shows vertebral compression fractures. Bone biopsy reveals reduced bone mass with normal mineralization.
What is the most likely diagnosis?

A- Osteoporosis

B- Osteomalacia

C- Hyperparathyroidism

D- Paget’s disease

A- Osteoporosis- Osteoporosis involves decreased bone mass with normal mineralization, leading to fragility fractures, especially in vertebrae and hips.

 

Read this Pathology MCQs Book

More Repeated USMLE Questions Step 1

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Dr Ray Makar

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