Repeated USMLE Questions Step 1- Review-172

Q- A child has chronic diarrhea and failure to thrive. Stool is positive for fat. The sweat chloride test is elevated.

Which mechanism explains the GI symptoms?

A- Decreased pancreatic enzyme secretion

B- Increased bile acid synthesis

C- Increased gastric acid production

D- Increased intestinal chloride secretion

A- Decreased pancreatic enzyme secretion- Cystic fibrosis causes thick secretions → pancreatic duct obstruction → malabsorption and steatorrhea.

 

Q- A patient has progressive weakness and ptosis that improves with rest. Autoantibodies are directed against postsynaptic acetylcholine receptors.

Which finding is expected?

A- Decreased ACh release at presynaptic terminal

B- Decreased muscle action potential amplitude with repeated stimulation

C- Increased AChE activity

D- Increased thymic mass

D- Increased thymic mass- Myasthenia gravis is associated with thymic hyperplasia or thymoma.

 

Q- A man presents with episodic palpitations, headache, and sweating. Urine shows elevated metanephrines.

The tumor most likely arises from which embryologic tissue?

A- Endoderm

B- Mesoderm

C- Neural crest

D- Surface ectoderm

C- Neural crest- Pheochromocytoma arises from chromaffin cells derived from neural crest.

 

Read this Review Book for Step 1 

More Repeated USMLE Questions Step 1

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Dr Ray Makar

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