Q- Which of the following differentiates neostigmine from pilocarpine?
A- Acceleration of heart rate
B- Prolonged skeletal muscle contraction
C- Stimulation of bowel motility
D- Stimulation of salivary glands
B- Prolonged skeletal muscle contraction- Neostigmine is an acetylcholinesterase inhibitor, so it increases acetylcholine at both muscarinic and nicotinic receptors, including the neuromuscular junction, leading to enhanced skeletal muscle contraction. Pilocarpine is a pure muscarinic agonist and has no effect on nicotinic receptors, so it does not cause prolonged skeletal muscle contraction.
Q- An 80 mg dose of a drug was administered to a patient. 40 mg was eliminated during the first hour. This drug follows first-order elimination kinetics.
Which of the following is the amount of the drug that remains 3 hours after administration?
A- 30 mg
B- 20 mg
C- 10 mg
D- None
C- 10 mg- The drug follows first-order kinetics, and since the amount decreased from 80 mg to 40 mg in 1 hour, its half-life is 1 hour.
Q- Which one of the following actions of epinephrine is blocked by prazosin?
A- Bronchial dilation
B- High stroke volume
C- Pupil dilation
D- Tachycardia
C- Pupil dilation- Prazosin is an α₁-adrenergic blocker. Epinephrine causes pupil dilation (mydriasis) through α₁ stimulation, so prazosin blocks this effect. Bronchial dilation is β₂-mediated, tachycardia is β₁-mediated, and increased stroke volume is also mainly β₁-mediated — none of these are blocked by prazosin.
I’m sorry. I didn’t include an explanation for some of them. I’m working on that. I have a lot of answers with explanations, though. Thank you for your comment.
I’m sorry. I didn’t include an explanation for some of them. I’m working on that. I have a lot of answers with explanations, though. Thank you for your comment.
Dr please give the answer with explanation
Thanks
Very good