Q- A 25-year-old woman presents to her physician at 28 weeks of gestation with general itching for one week. Itching is worse at night and more pronounced on the soles and palms. She has no history of allergy or dermatological diseases. She is compliant with regular examinations, and her pregnancy is uncomplicated. Her physical and obstetric examinations are unremarkable. Laboratory tests reveal normal full blood count, renal function tests, and blood coagulation tests.
Her liver function tests are as follows:
ALT 47 IU/L
AST 55 IU/L
Alkaline phosphatase 356 IU/L
Total bilirubin 1.9
Bile acids 15 micromol/L
Serology for hepatitis is negative
What is the best treatment for this woman’s itching?
A- Hospitalization and induction of labor
B- Ursodeoxycholic acid and vitamin K
C- Diphenhydramine
D- No treatment and repeat liver function tests in a week
Answer:
Ursodeoxycholic acid improves bile flow, lowers bile acid levels, and reduces fetal risks. Vitamin K supplementation corrects potential deficiency due to malabsorption from cholestasis. Delivery is typically considered around 37–38 weeks to reduce risk of stillbirth.
Correct answer is B
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sir could it be pregnancy induced cholestasis?? if not why?
Thank you Dr Shawqi…I appreciate your time to visit my website.
Very nice Q&A