Repeated USMLE Questions Step 1- Review- 61- Pharmacology

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Q- Which of the following is the mechanism of action of metoprolol in treating hypertension and arrhythmias?

A- β1 -Selective adrenoreceptor agonist

B- β1 -Selective adrenoreceptor antagonist

C- Blocks Ca 2+ entry in vascular smooth muscle cells

D- Reduces production of angiotensin II

B- β1 -Selective adrenoreceptor antagonist- Metoprolol is a selective beta-blocker.



Q- Which of the following is the receptor site of action of sumatriptan?

A- Dopamine receptor

B- GABAB receptor

C- Glycine receptor

D- Serotonin 5-HT

D- Serotonin 5-HT- Sumatriptan activate this receptor which inhibits the activity of adenylyl cyclase to decrease cAMP accumulation leading to contraction of arterial smooth muscle in carotid and cranial circulation.



Q- Which of the following drugs is a weak partial agonist of estrogen receptor in most tissues?

A- Clomiphene

B- Fulvestrant

C- Raloxifene

D-Tamoxifen

A- Clomiphene- It is the only one on the list that is weak partial agonist of estrogen receptor. Fulvestrant is a pure anti-estrogen. Raloxifene and tamoxifen are estrogen antagonists but their activity is tissue-specific.



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