Pharmacology MCQs- 226

A 62-year-old man who has a history of various drug overdose incidents presents to the emergency room after administration of a high dose of aspirin.

Which set of these findings characterizes this condition?

A-Metabolic acidosis and respiratory acidosis

B-Metabolic acidosis and respiratory alkalosis

C-Metabolic alkalosis and respiratory acidosis

D-Metabolic alkalosis and respiratory alkalosis


Salicylate intoxication is characterized by respiratory alkalosis caused by hyperventilation due to direct stimulation of the respiratory center. It leads to compensatory excretion of large amounts of potassium and sodium bicarbonate in urine leading of metabolic acidosis. Gastric lavage and alkalization of urine are the first line of treatment of aspirin overdose.

The correct answer is B

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