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Repeated USMLE Questions Step 1- Review- 57- Pharmacology

Q- Which one of the following drugs acts by inhibition of lipolysis in adipose tissues and reduction of hepatic VLDL synthesis?

A- Atorvastatin

B- Cholestyramine

C- Ezetimibe

D- Niacin

D- Niacin- It inhibits hormone-sensitive lipase. Atorvastatin inhibits conversion of HMG-CoA to mevalonate which is a cholesterol precursor. Cholestyramine prevents intestinal absorption of bile acids with ezetimibe prevent cholesterol absorption at small intestine brush border.



Q- Which one of the following hypoglycemic drugs acts by lowering postprandial hyperglycemia through inhibition of intestinal brush border alpha-glucosidases?

A- Linagliptin

B- Miglitol

C- Rosiglitazone

D- Sitagliptin

B- Miglitol- It is the only alpha-glucosidase on the list. Along with acarbose, they delayed carbohydrate hydrolysis and glucose absorption. Linagliptin and sitagliptin acts by inhibition of DPP-4 enzyme and glucagon release while rosiglitazone regulates glucose metabolism and fatty acid storage.



Q- Which one of the following drugs is a synthetic analog of aldosterone and used in primary adrenal deficiency to replace mineralocorticoid?

A- Cinacalcet

B- Demeclocycline

C- Fludrocortisone

D- Sevelamer

C- Fludrocortisone- It is the only one on the list that is used in primary adrenal deficiency. Cinacalcet is used in secondary hyperparathyroidism. Demeclocycline is used in SIADH while sevelamer is used in hyperphosphatemia.



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