Q- A patient presents with symptoms consistent with gout. Which of the following is the reason for avoiding use of aspirin in this patient?
A- Aspirin reduces renal clearance of uric acid
B- Aspirin stimulates protein absorption
C- Colchicine is stronger than aspirin
A- Aspirin reduces renal clearance of uric acid- Aspirin can competitively inhibit the renal excretion of uric acid, leading to an increase in serum uric acid levels. This can exacerbate gout symptoms or trigger an attack in individuals with gout. Colchicine is more effective in reducing inflammation associated with gout.
Q- Which of the following is the role of imatinib in treating a case of Philadelphia chromosome-positive chronic myeloid leukemia?
A- It inhibits the BCR-ABL protein
B- It inhibits the HER2/neu protein
C- It inhibits the epithelial growth factor
D- It inhibits the microtubule assembly during mitosis
A- It inhibits the BCR-ABL protein- Chromosomal abnormality is CML is the translocation of the BCR gene on C22 with the Abl gene on C9 which is known as Philadelphia chromosome. It is treated with tyrosine kinase inhibitors such as imatinib.
Q- Which one of the following screening tests is recommended every other year for a woman at the age of 50, assuming normal test results?
A- Colonoscopy
B- DEXA scan
C- Mammogram
D- Pap smear
C- Mammogram- Colonoscopy is recommended every 10 years for normal results. Pap smear is done 3-5 years. DEXA scan starts at the age of 65 for osteoporosis screening.
