USMLE Q Bank Step 1- 217

A 56-year-old man with a history of type 2 diabetes presents to his physician for a follow up. He complains of recurrent hypoglycemic reactions to his medications.

Which of these medications is most likely responsible for this patient’s hypoglycemic reactions?

A- Glyburide

B- Glucagon

C- Metformin

D- Acarbose

E- Rosiglitazone


The only medication of the listed ones that its mechanism is to release insulin from the pancreas is glyburide. Release of insulin in type 2 diabetes causes hypoglycemic reactions. Other drugs lowers blood glucose through other mechanisms i.e. euglycemic as metformin or preventing postprandial hypoglycemia as acarbose.

The correct answer is A

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