USMLE Q Bank Step 1- 219- Repeated USMLE Questions

Q- Transplantation of the left lobe of liver is performed for a patient with hepatic failure. A year later, the size of the recipient liver becomes greater than at the time of the transplantation. Which one of the following cellular changes most likely takes place in the patient’s liver?

A- Anaplasia

B- Dysplasia

C- Hyperplasia

D- Metaplasia

C- Hyperplasia- Hepatocytes are stable cells and are able to re-enter the cell cycle and regenerate. The other choices are pathological changes.



Q- A 64-year-old woman complains of low back pain for 1 week. Her pain and tenderness are localized over the lumbar spine and exaggerated by movement. Her physician prescribes her a phosphonate drug.

What is the mechanism of action of this drug for this patient?

A- Decrease osteoclast activity

B- Decrease parathormone activity

C- Increase osteoblast activity

D- Increase vitamin D absorption

E- Increase urinary calcium reabsorption

A- Decrease osteoclast activity- This is most likely a case of osteoporosis. Phosphonates improve this condition through decreasing osteoclast activity. Bisphosphonates are also the drug of choice in Paget’s disease of bone. Osteoblast activity is regulated by growth factors and parathyroid hormone. Calcium level of the blood is regulated by parathormone and vitamin D in addition to other factors.



Q- An autopsy is performed for an obese male died of a heart attack. Microscopic examination of the heart shows the myocardial fibers are increased in size and adipocytes are interdigitating with these fibers. Which of the following most likely explains the presence of adipocytes in the patient’s heart?

A- Cholesterol deposition

B- Fatty infiltration

C- Steatosis

D- Xanthomatosis

B- Fatty infiltration- This is a normal deposition of normal fat cells (adipocytes) in the tissues of obese persons.



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2 thoughts on “USMLE Q Bank Step 1- 219- Repeated USMLE Questions”

  1. Thank you samir

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