Repeated USMLE Questions Step 1 Review | 166

Q- A 34-year-old woman presents with chronic diarrhea and abdominal pain. Colonoscopy reveals transmural inflammation with skip lesions.
Which complication is most likely in this condition?

A- Toxic megacolon

B- Colorectal adenocarcinoma

C- Fistula formation

D- Primary sclerosing cholangitis

C- Fistula formation- Crohn disease causes transmural inflammation, predisposing to fistulas, strictures, and abscesses.

Q- A 58-year-old man presents with fatigue and easy bruising. Peripheral smear shows blasts with Auer rods.
Which cytogenetic abnormality is most characteristic of this disease?

A- t(9;22)

B- t(15;17)

C- t(8;14)

D- del(5q)

B- t(15;17)- Acute promyelocytic leukemia is associated with t(15;17), involving the PML-RARα fusion gene, and is treated with all-trans retinoic acid.

Q- A 61-year-old man presents with progressive jaundice, weight loss, and pruritus. Imaging reveals dilation of the bile ducts and a mass near the hepatic hilum.
Which tumor is most likely responsible for this finding?

A- Hepatocellular carcinoma

B- Cholangiocarcinoma

C- Gallbladder adenocarcinoma

D- Pancreatic neuroendocrine tumor

B- Cholangiocarcinoma- Cholangiocarcinoma arises from bile duct epithelium and can obstruct bile flow, leading to jaundice and pruritus. Risk factors include primary sclerosing cholangitis and chronic biliary inflammation.

Repeated USMLE Questions Step 1 Review-166- Pathology

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