Pharmacology MCQs- 242

Q- Naloxone is the treatment of choice of which one of the following toxicities?

A- Amitriptyline toxicity

B- Citalopram overdose

C- Hydrocodone toxicity

D- Methylphenidate overdose

C- Hydrocodone toxicity- Naloxone is an opioid antagonist used to reverse opioid toxicity, including hydrocodone overdose. It is not effective for tricyclic antidepressants (amitriptyline), SSRIs (citalopram), or stimulants (methylphenidate).

Q- Administration of clopidogrel with aspirin is an example of which of the following drug interactions?

A- Additive

B- Permissive

C- Synergistic

D- Tachyphylactic

A- Additive- Aspirin and clopidogrel each inhibit platelet aggregation through different mechanisms. When given together, their antiplatelet effects add up, producing a stronger combined effect that equals the sum of their individual actions. This is additive, not synergistic (which would be greater than the sum).

Q- Which of the following medications prevents cholesterol absorption at small intestine brush border?

A- Colestipol

B- Ezetimibe

C- Fenofibrate

D- Niacin

B- Ezetimibe- Ezetimibe blocks the NPC1L1 transporter at the small-intestine brush border, preventing dietary and biliary cholesterol absorption. The other drugs lower lipid levels by different mechanisms.