Pharmacology MCQs- 265

Q- Bioavailability of a medication is maximal when it has which of the following factors?

A- High ionization

B- High lipid solubility

C- High plasma binding

D- High water solubility

B- High lipid solubility- Medications with high lipid solubility cross membranes easily and therefore have higher bioavailability, especially when given orally. High ionization, high plasma protein binding, and high water solubility all reduce bioavailability.

Q- Which of the following is the major indication of ondansetron in patients receiving chemotherapy?

A- Hair loss

B- Nausea and vomiting

C- Headache

D- GERD

B- Nausea and vomiting- Ondansetron is a serotonin (5-HT₃) receptor antagonist used primarily to prevent nausea and vomiting, especially in patients receiving chemotherapy.

Q- Prazosin blocks which of the following actions of epinephrine?

A- Bronchodilation

B- High stroke volume

C- Mydriasis

D- Tachycardia

C- Mydriasis- Prazosin is an α₁-adrenergic blocker. Epinephrine causes pupil dilation (mydriasis) through α₁ stimulation, so prazosin blocks this effect. Bronchodilation (β₂), increased stroke volume (β₁), and tachycardia (β₁) are not blocked by prazosin.

 

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