Repeated USMLE Questions Step 1 Review-150- Pathology

by

Q- A 52-year-old man presents with chronic cough, hemoptysis, and digital clubbing. Chest X-ray reveals a coin lesion in the lung. Biopsy shows malignant glandular structures producing mucin.
What is the most likely diagnosis?

A- Adenocarcinoma

B- Large cell carcinoma

C- Small cell carcinoma

D- Squamous cell carcinoma

A- Adenocarcinoma- Adenocarcinoma is the most common lung cancer in both smokers and nonsmokers. It tends to be peripheral and shows mucin-producing glandular cells.

 

Q- A 36-year-old woman presents with fatigue and pallor. Peripheral smear shows microcytic, hypochromic red blood cells with basophilic stippling. She works in a battery factory.
What is the most likely diagnosis?

A- Iron deficiency anemia

B- Lead poisoning

C- Sideroblastic anemia

D- Thalassemia

B- Lead poisoning- Lead inhibits heme synthesis and causes basophilic stippling of RBCs, abdominal pain, and neuropathy. Common in battery, paint, or smelting workers.

 

Q- A 70-year-old woman presents with severe bone pain and recurrent fractures. Laboratory tests show hypercalcemia, normal PTH, and elevated ALP. Bone biopsy reveals lytic lesions with multinucleated giant cells.
Which of the following is the most likely diagnosis?

A- Multiple myeloma

B- Osteoporosis

C- Osteosarcoma

D- Paget disease of bone

A- Multiple myeloma- Multiple myeloma causes osteolytic lesions due to malignant plasma cells producing osteoclast-activating factors. Presents with bone pain, fractures, and hypercalcemia.

 

Read this Pathology MCQs Book

More Repeated USMLE Questions Step 1

author avatar
Dr Ray Makar
See Full Bio

Leave a Comment