Repeated USMLE Questions Step 1 Review-173- Pharmacology

Q- A patient with Parkinson’s disease is treated with selegiline. What is the primary mechanism of this drug?

A- Inhibition of catechol-O-methyltransferase

B- Inhibition of monoamine oxidase B

C- Stimulation of dopamine receptors

D- Stimulation of muscarinic receptors

B- Inhibition of monoamine oxidase B- Selegiline inhibits MAO-B in the brain, decreasing dopamine breakdown and increasing dopamine availability.

 

Q- A patient treated with verapamil develops constipation and bradycardia. What class of drug does verapamil belong to?

A- Beta-blockers

B- Calcium channel blockers

C- Potassium channel blockers

D- Sodium channel blockers

B- Calcium channel blockers- Verapamil blocks L-type calcium channels, decreasing cardiac conduction and contractility while also relaxing vascular smooth muscle.

 

Q- A patient with acute gout is treated with colchicine. What is the primary mechanism of this drug?

A- Inhibition of uric acid synthesis

B- Inhibition of xanthine oxidase

C- Inhibition of neutrophil microtubule formation

D- Increased renal uric acid secretion

C- Inhibition of neutrophil microtubule formation- Colchicine disrupts microtubule polymerization, reducing neutrophil migration and inflammatory response to urate crystals.

 

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Dr Ray Makar

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