Q- A 64-year-old man with a long history of smoking presents with hematuria. Cystoscopy reveals a papillary tumor arising from the bladder mucosa.
Which molecular alteration is most commonly associated with low-grade papillary urothelial carcinoma?
A- KRAS mutation
B- FGFR3 mutation
C- BRAF mutation
D- APC mutation
Q- A 14-year-old boy presents with a rapidly enlarging, painful mass around the distal femur. X-ray shows a destructive bone lesion with a “sunburst” periosteal reaction.
What is the most likely diagnosis?
A- Chondrosarcoma
B- Ewing sarcoma
C- Osteochondroma
D- Osteosarcoma
Q- A 58-year-old woman with obesity and type 2 diabetes presents with abnormal uterine bleeding. Endometrial biopsy reveals atypical glandular proliferation.
Which malignancy is she at greatest risk of developing?
A- Cervical squamous carcinoma
B- Endometrial carcinoma
C- Ovarian serous carcinoma
D- Vaginal carcinoma
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More Repeated USMLE Questions Step 1
