A Case of Hyperlipidemia



A 30-year-old man presents to the emergency room with excruciating chest pain and shortness of breath for an hour. Past, surgical and familial histories are unremarkable except that his father died of heart attack at the age of 32. Imaging studies and laboratory tests confirm the diagnosis of myocardial infarction. What is the most likely precipitation factor contributing to his condition?

A- Alcohol abuse

B- Atherosclerosis

C- Familial hypercholesterolemia

D- Type II diabetes

C- Familial hypercholesterolemia- This is the most common cause of coronary artery diseases in young age.



Q- Which of the following substances lines the vesicles that involved in LDL uptake by hepatocytes?

A- Chylomicrons

B- Clathrin

C- Laminin

D- Transferrin

B- Clathrin- Clathrin-coated vesicles carry the LDL into the cytoplasm of hepatic cells.



Q- Which of the following is the mechanism of action of the main drug used for the treatment of high LDL cholesterol?

A- Breakdown of adipose tissues

B- Decreased synthesis of LDL receptors

C- Inhibition of HMG-CoA reductase

D- Inhibition of cholesterol uptake by the liver

C- Inhibition of HMG-CoA reductase- Statins are the drug of choice for high cholesterol.



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