Medical Question of the Day- 33

Workers in the aniline dye industry are more susceptible to bladder cancer than general population. Meanwhile, studies show that animals, when exposed to beta-naphthylamine develop liver cancer but not bladder cancer.

What is the most likely explanation of this finding?

A-Metabolism of beta-naphthylamine by human cytochrome 450 system in the liver

B-Detoxification of beta-naphthylamine by glucuronic acid conjugation.

C-Human urinary glucuronidase splits beta-naphthylamine into glucuronic acid and a toxic metabolite.

D-Beta-naphthylamine is directly carcinogenic to human bladder


Urinary glucuronidase is found only in human. It splits beta-naphthylamine into glucuronic acid and a toxic carcinogenic metabolite. This metabolite is the responsible agent for bladder cancer in human. Other options are distractions.

The correct answer is C

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9 thoughts on “Medical Question of the Day- 33”

  1. Hello Dr. Ray, thanks a lot. your facebook posts have helped me to study on the go! God bless you and continue the help. Would really love to own a copy of your book. I will pay for it.

  2. You are absolutely right Dr Lala. I edited it and I will send a copy of my book to you. Thank you so much.

  3. I suspect answer choice C should read “Human urinary glucuronidase”, not “Human urinary glucuronides”.

  4. Thank you Dr Divya Vani

  5. Thank you Dr Mina

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