Workers in the aniline dye industry are more susceptible to bladder cancer than general population. Meanwhile, studies show that animals, when exposed to beta-naphthylamine develop liver cancer but not bladder cancer.
What is the most likely explanation of this finding?
A-Metabolism of beta-naphthylamine by human cytochrome 450 system in the liver
B-Detoxification of beta-naphthylamine by glucuronic acid conjugation.
C-Human urinary glucuronidase splits beta-naphthylamine into glucuronic acid and a toxic metabolite.
D-Beta-naphthylamine is directly carcinogenic to human bladder
Urinary glucuronidase is found only in human. It splits beta-naphthylamine into glucuronic acid and a toxic carcinogenic metabolite. This metabolite is the responsible agent for bladder cancer in human. Other options are distractions.
The correct answer is C
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