Workers in the aniline dye industry are more susceptible to bladder cancer than general population. Meanwhile, studies show that animals, when exposed to beta-naphthylamine develop liver cancer but not bladder cancer.
What is the most likely explanation of this finding?
A-Metabolism of beta-naphthylamine by human cytochrome 450 system in the liver
B-Detoxification of beta-naphthylamine by glucuronic acid conjugation.
C-Human urinary glucuronidase splits beta-naphthylamine into glucuronic acid and a toxic metabolite.
D-Beta-naphthylamine is directly carcinogenic to human bladder
Urinary glucuronidase is found only in human. It splits beta-naphthylamine into glucuronic acid and a toxic carcinogenic metabolite. This metabolite is the responsible agent for bladder cancer in human. Other options are distractions.
The correct answer is C
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9 thoughts on “Medical Question of the Day- 33”
Hello Dr. Ray, thanks a lot. your facebook posts have helped me to study on the go! God bless you and continue the help. Would really love to own a copy of your book. I will pay for it.
Sorry, I don’t have one but you can visit this website to get the full version: https://medical-usmle.com/membership-account/membership-levels/
hello dr ray..can u send me a pdf version of repeated question please thanks ….email@example.com
You are absolutely right Dr Lala. I edited it and I will send a copy of my book to you. Thank you so much.
I suspect answer choice C should read “Human urinary glucuronidase”, not “Human urinary glucuronides”.
Thank you Dr Divya Vani
Thank you Dr Mina