A 19-year-old man with a history of immunodeficiency disease develops fever. Prophylactic measures including some medications are initiated. A few days later, the patient develops acute renal failure.
Which of these drugs is most likely responsible?
A-Acyclovir
B-Amphotericin B
C-Ampicillin
D-Ciprofloxacin
E-Nystatin
Answer
Amphotericin B has been known for causing renal problems through decreasing creatinine clearance. Liposomal preparation of this drug may reduce renal side effects. Acyclovir, ampicillin, ciprofloxacin and nystatin less likely affect renal functions.
The correct answer is B