Pharmacology MCQs- 279

Q- Which of the following side effects occurs with both tricyclic antidepressants and phenothiazines?

A- Excessive salivation

B- Orthostatic hypotension

C- Seizures

D- Weight loss

B- Orthostatic hypotension- Both types of drugs block alpha-adrenergic receptors which may cause postural hypotension. They also decrease salivation, decrease seizures’ incidents and lead to weight gain.

Q- Which of the following medications is useful to distinguish nephrogenic from neurogenic diabetes insipidus?

A- Acetazolamide

B- Demeclocycline

C- Desmopressin

D- Hydrochlorothiazide

C- Desmopressin- It treats neurogenic DI through selective activation of V2 receptors in the kidney. Nephrogenic DI is treated with thiazides.

Q- Which of the following drugs is most likely protective against the toxicity of doxorubicin?

A- Dexrazoxane

B- Leucovorin

C- Mensa

D- Vitamin C

A-Dexrazoxane- It is iron-chelating agent that prevents the formation of free radicals and reduces the well-known cardiotoxicity.

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