Q- Which of the following side effects occurs with both tricyclic antidepressants and phenothiazines?
A- Excessive salivation
B- Orthostatic hypotension
C- Seizures
D- Weight loss
B- Orthostatic hypotension- Both types of drugs block alpha-adrenergic receptors which may cause postural hypotension. They also decrease salivation, decrease seizures’ incidents and lead to weight gain.
Q- Which of the following medications is useful to distinguish nephrogenic from neurogenic diabetes insipidus?
A- Acetazolamide
B- Demeclocycline
C- Desmopressin
D- Hydrochlorothiazide
C- Desmopressin- It treats neurogenic DI through selective activation of V2 receptors in the kidney. Nephrogenic DI is treated with thiazides.
Q- Which of the following drugs is most likely protective against the toxicity of doxorubicin?
A- Dexrazoxane
B- Leucovorin
C- Mensa
D- Vitamin C
A-Dexrazoxane- It is iron-chelating agent that prevents the formation of free radicals and reduces the well-known cardiotoxicity.