Repeated USMLE Questions Step 1- Pharmacology- 292

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Q- Which of the following is the mechanism of action of selegiline in treating Parkinson’s disease?

A- Agonist at dopamine receptors

B- Blocks catechol-O-methyltransferase (COMT)

C- Inhibition of MAO type B to reserve dopamine

D- Precursor of dopamine

C- Inhibition of MAO type B to reserve dopamine- Selegiline inhibits the degradation of dopamine by MAO type B.



Q- Which of the following is the mechanism of action of zileuton for asthma?

A- Inhibition of 5-lipoxygenase

B- Inhibition of phosphodiesterase

C- Inhibition of Phospholipase A

D- Stimulation of beta-2 receptors

A- Inhibition of 5-lipoxygenase- This mechanism inhibits the synthesis of leukotrienes from arachidonic acid.



Q- Which one of the following effects is caused by the administration of mecamylamine?

A- Hypertension

B- Pupillary constriction

C- Tachycardia

D- Tremors

C- Tachycardia- This drug is a ganglion blocker usually administered during surgery to control hypotension and blood loss. It blocks parasympathetic control of the heart causing tachycardia.

 

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Dr Ray Makar
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2 thoughts on “Repeated USMLE Questions Step 1- Pharmacology- 292”

  1. Thank you. I hope it helps you in your examinations. Good luck.

  2. Good information

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