Pharmacology MCQs- 292



Q- Which of the following is the mechanism of action of selegiline in treating Parkinson’s disease?

A- Agonist at dopamine receptors

B- Blocks catechol-O-methyltransferase (COMT)

C- Inhibition of MAO type B to reserve dopamine

D- Precursor of dopamine

C- Inhibition of MAO type B to reserve dopamine- Selegiline inhibits the degradation of dopamine by MAO type B.



Q- Which of the following is the mechanism of action of zileuton for asthma?

A- Inhibition of 5-lipoxygenase

B- Inhibition of phosphodiesterase

C- Inhibition of Phospholipase A

D- Stimulation of beta-2 receptors

A- Inhibition of 5-lipoxygenase- This mechanism inhibits the synthesis of leukotrienes from arachidonic acid.



Q- Which one of the following effects is caused by administration of mecamylamine?

A- Hypertension

B- Pupillary constriction

C- Tachycardia

D- Tremors

C- Tachycardia- This drug is a ganglion blocker usually administered during surgery to control hypotension and blood loss. It blocks parasympathetic control of the heart causing tachycardia.



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