Repeated USMLE Questions Step 1 Review- 136- Pharmacology

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Q- Which of the following drugs is a reversible cholinesterase inhibitor used in the management of myasthenia gravis?

A- Atropine

B- Neostigmine

C- Pralidoxime

D- Succinylcholine

B- Neostigmine- Neostigmine is a reversible acetylcholinesterase inhibitor that increases acetylcholine at the neuromuscular junction, improving muscle strength in myasthenia gravis.

 

Q- A patient with atrial fibrillation is prescribed warfarin. Which of the following factors will increase the anticoagulant effect of warfarin?

A- Vitamin K deficiency

B- Rifampin therapy

C- Liver disease

D- Chronic alcohol use

C- Liver disease- Warfarin’s effect is enhanced when clotting factor synthesis is decreased, as seen in liver disease. Rifampin and chronic alcohol induce metabolism (decreasing effect), while vitamin K opposes warfarin’s action.

 

Q- Which one of the following antibiotics is most associated with tendinitis and tendon rupture?

A- Ciprofloxacin

B- Azithromycin

C- Doxycycline

D- Amoxicillin

A- Ciprofloxacin- Fluoroquinolones such as ciprofloxacin impair collagen synthesis and increase the risk of tendon rupture, specifically in older patients or those on corticosteroids.

 

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Dr Ray Makar
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