Repeated USMLE Questions Step 1 Review- 137- Pathology

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Q- A 60-year-old woman presents with progressive jaundice and weight loss. Imaging shows a mass at the head of the pancreas.

Which of the following is the most likely paraneoplastic finding?

A- Cushing syndrome

B- Hypercalcemia due to PTHrP secretion

C- Hyponatremia due to SIADH

D- Migratory thrombophlebitis (Trousseau syndrome)

D- Migratory thrombophlebitis (Trousseau syndrome)- Pancreatic adenocarcinoma is strongly associated with Trousseau syndrome (recurrent venous thrombosis at different sites).

 

Q- A 27-year-old man develops acute renal failure after a sore throat 2 weeks ago. Urinalysis shows hematuria with red blood cell casts. Light microscopy of a kidney biopsy reveals hypercellular glomeruli.

Which of the following is the most likely diagnosis?

A- Membranous nephropathy

B- Minimal change disease

C- Post-streptococcal glomerulonephritis

D- Rapidly progressive glomerulonephritis

C- Post-streptococcal glomerulonephritis- This condition follows group A streptococcal infection. It presents with hematuria, edema, hypertension, and RBC casts. Biopsy shows hypercellular glomeruli due to immune complex deposition.

 

Q- A 50-year-old man presents with chronic cough and weight loss. A chest X-ray reveals a cavitary lesion in the upper lobe. Biopsy shows caseating granulomas with acid-fast bacilli.

Which organism is responsible for this pathology?

A- Aspergillus fumigatus

B- Mycobacterium tuberculosis

C- Histoplasma capsulatum

D- Klebsiella pneumoniae

B- Mycobacterium tuberculosis- TB classically produces caseating granulomas, especially in the upper lobes. Acid-fast bacilli on Ziehl-Neelsen stain confirm the diagnosis.

 

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2 thoughts on “Repeated USMLE Questions Step 1 Review- 137- Pathology”

  1. Thank you, dear. Dr., for your feedback.

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