Repeated USMLE Questions Step 1- Pharmacology- 305

Q- A 73-year-old patient with multiple myeloma has been treated with high doses of doxorubicin. Which of the following may develop during this treatment?

A-Bladder hemorrhage



D-Hemolytic anemia

B-Cardiomyopathy- High doses of doxorubicin in an old patient can lead to cardiomyopathy resulting in congestive heart failure and pulmonary edema.

Q- Heparin acts by binding to which of the following substances to achieve its anticoagulant activity?

A-Antithrombin III

B-Factor V

C-Factor VIII


A-Antithrombin III- Heparin binds to this coagulation inhibitor to increase its activity. Other choices are clotting factors and do not interact with heparin.

Q- Prolonged use of which one of the following diuretics can lead to hyperkalemia and gynecomastia?





D-Spironolactone- It is a potassium-sparing diuretic acts by blocking aldosterone at its receptor resulting in high serum potassium and gynecomastia.

Other Pharmacology MCQs

4 thoughts on “Repeated USMLE Questions Step 1- Pharmacology- 305”

  1. Thank you so much Dr. Sadiq Ulah

  2. Thank you so much Dr. Sadiq.

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