Repeated USMLE Questions Step 1- Review- 28

Q- Which one of the following tumors is commonly associated with mutations affecting tumor suppressor gene (APC) and TP 53?

A- Colorectal adenocarcinoma

B- Hepatocellular carcinoma

C- Invasive ductal carcinoma of the breast

D- Small cell carcinoma of the lung

A- Colorectal adenocarcinoma- It commonly affects the intestinal epithelium of the colon and rectum. It counts for 95% of colorectal cancers.

Q- Absorption of levodopa-carbidopa is reduced when taken with meals rich in which of the following nutrients?

A- Carbohydrate

B- Fat

C- Protein

C-Protein- Amino acids compete with this Parkinson’s disease medication for carrier sites which leads to reduced absorption. It should be taken on empty stomach and one hour before meals. 

Q- A young adult complains of fever, sore throat and lymphadenopathy for 5 days. Examination reveals bilateral enlarged tender cervical lymph nodes and enlarged spleen. Which of the following organisms is most likely responsible for this patient’s condition?


B-Epstein-Barr virus

C-Human papillomavirus

D-Human immunodeficiency virus (HIV)

B-Epstein-Barr virus- This is a typical case of infectious mononucleosis. The young age, fever, sore throat and lymphadenopathy are highly suggestive of this diagnosis.



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